pestilence

Noun
  1. A serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal (synset 114162173)
  2. Any epidemic disease with a high death rate (synset 114099961)
  3. A pernicious and malign influence that is hard to get rid of (synset 105701634)
    "racism is a pestilence at the heart of the nation"; "according to him, I was the canker in their midst"

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