exacerbation

Noun
  1. Action that makes a problem or a disease (or its symptoms) worse (synset 100375643)
    "the aggravation of her condition resulted from lack of care"
    is a type of: intensification - action that makes something stronger or more extreme
    same as: aggravation
  2. Violent and bitter exasperation (synset 101224646)
    "his foolishness was followed by an exacerbation of their quarrel"
    is a type of: exasperation - actions that cause great irritation (or even anger)

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