whammy

Noun
  1. A serious or devastating setback (synset 107491232)
    is a type of: black eye, blow, reversal, reverse, setback - an unfortunate happening that hinders or impedes; something that is thwarting or frustrating
  2. An evil spell (synset 107175075)
    "a witch put a curse on his whole family"; "he put the whammy on me"
    is a type of: charm, magic spell, magical spell, spell - a verbal formula believed to have magical force
    same as: curse, hex, jinx

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