vicissitude

Noun
  1. A variation in circumstances or fortune at different times in your life or in the development of something (synset 107352294)
    "the project was subject to the usual vicissitudes of exploratory research"
    is a type of: fluctuation, variation - an instance of change; the rate or magnitude of change
  2. Mutability in life or nature (especially successive alternation from one condition to another) (synset 104748895)
    is a type of: mutability, mutableness - the quality of being capable of mutation

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